Bioorganic and Medicinal Chemistry Letters p. 1741 - 1744 (1998)
Update date:2022-07-29
Topics:
Lee
Palmer
Wilson
Denny
A four-step synthesis of 5-[N,N-bis(2-chloroethyl)amino]-1-methyl-2- nitroimidazole from 1-methyl2-nitroimidazole is described. This compound showed similar hypoxia-selective cytotoxicity to the dinitrobenzamide mustard SN 23862 in UV4 cells (ca. 40-fold), and superior selectivity (>7-fold) in repaircompetent AA8 cells.
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