Direct Chain Elongation of N-Carbamoylpyroglutamate. An Efficient Synthesis of (-)-Pyrrolidine-2,5-Dicarboxylic Acid

DOI: 10.1246/cl.1987.2091

Source and publish data:

Chemistry Letters p. 2091 - 2094 (1987)

Update date:2022-08-02

Topics:

Authors:

Ohta, Tomihisa

Hosoi, Akio

Kimura, Toshihiko

Nozoe, Shigeo

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Article abstract of DOI:10.1246/cl.1987.2091

(-)-Pyrrolidine-2,5-dicarboxylic acid, an acidic amino acid component of marine red Schizymenia dubyi, has been synthesized with a direct chain elongation reaction of N-carbamoylpyroglutamates at C-5 and a pyrrolidine ring formation.

Full text of DOI:10.1246/cl.1987.2091

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