European Journal of Medicinal Chemistry p. 461 - 467 (1991)
Update date:2022-08-05
Topics:
Loubinoux, B
Colin, JL
Thomas, V
Synthesis and biological activities of oxolinic acid pro-drugs.Antiseptic phenols, anti-inflammatory acids and polyethyleneglycol moieties have been attached by labile bonds to oxolinic acid giving pro-drugs with anti-bacterial activities.Some of them are more soluble in water, exhibit a more sustained action in the time and give higher plasma and tissue concentrations compared with the free drug.
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