Synthesis of Optically Pure α-Alkylated α-Amino Acids and a Single-Step Method for Enatiomeric Excess Determination

DOI: 10.1021/jo00243a049

Source and publish data:

Journal of Organic Chemistry p. 1826 - 1827 (1988)

Update date:2022-08-02

Topics:

Authors:

Kruizinga, Wim H.

Bolster, John

Kellogg, Richard M.

Kamphuis, Johan

Boesten, Wilhelmus H. J.

et al. et al.

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Article abstract of DOI:10.1021/jo00243a049

A method for the enzymatic resolution of the amides of some racemic α-alkylated amino acids is described as well as a method involving derivatization with (S)-2-chloropropionyl chloride followed by 1H NMR analysis to establish the enantiomeric excesses of the free amino acids.

Full text of DOI:10.1021/jo00243a049

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