Phosphinic Acid Inhibitors of D-Alanyl-D-alanine Ligase

DOI: 10.1021/jm00117a017

Source and publish data:

Journal of Medicinal Chemistry p. 1772 - 1778 (1988)

Update date:2022-08-04

Topics: Inhibitors Experimental Phosphinic acid

Authors:

Parsons, William H.

Patchett, Arthur A.

Bull, Herbert G.

Schoen, William R.

Taub, David

et al. et al.

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Article abstract of DOI:10.1021/jm00117a017

We report the synthesis of a series of phosphinic acid dipeptide analogues, NH2CH(R¹)PO(OH)CH2CH(R²)CO2H, related to DAla-DAla.The best of these compounds are potent, essentially irreversible inhibitors of DAla-DAla ligase, and their

Full text of DOI:10.1021/jm00117a017

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