Journal of Medicinal Chemistry p. 1772 - 1778 (1988)
Update date:2022-08-04
Topics: Inhibitors Experimental Phosphinic acid
Parsons, William H.
Patchett, Arthur A.
Bull, Herbert G.
Schoen, William R.
Taub, David
et al.
We report the synthesis of a series of phosphinic acid dipeptide analogues, NH2CH(R1)PO(OH)CH2CH(R2)CO2H, related to DAla-DAla.The best of these compounds are potent, essentially irreversible inhibitors of DAla-DAla ligase, and their
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