Nonisomerizable Analogues of (Z)- and (E)-4-Hydroxytamoxifen. Synthesis and Endocrinological Properties of Substituted Diphenylbenzocycloheptenes

DOI: 10.1021/jm00402a005

Source and publish data:

Journal of Medicinal Chemistry p. 1285 - 1290 (1988)

Update date:2022-07-29

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Authors:

McCague, Raymond

Leclercq, Guy

Jordan, V. Craig

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Article abstract of DOI:10.1021/jm00402a005

Substituted 8,9-diphenyl-6,7-dihydro-5H-benzocycloheptenes 6-8, which are ring-fused analogues of (Z)-trans-4-hydroxytamoxifen, (E)-cis-tamoxifen, and (E)-cis-4-hydroxytamoxifen, were synthesized from 7-methoxy-1-benzosuberone.The hydroxy compounds 6 and

Full text of DOI:10.1021/jm00402a005

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