Chemical modification of an antitumor alkaloid, 20(S)-camptothecin: Glycosides, phosphates and sulfates of 7-ethyl-10-hydroxycamptothecin

DOI: 10.1248/cpb.40.131

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 131 - 135 (1992)

Update date:2022-07-29

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Authors:

Yaegashi

Nokata Nokata

Sawada Sawada

Furuta Furuta

Yokokura

Miyasaka

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Article abstract of DOI:10.1248/cpb.40.131

Water-soluble derivatives having the lactone ring intact were synthesized starting from 7-ethyl-10-hydroxycamptothecin (1). Glycosides (2) of the phenolic hydroxyl group of 1 were obtained by reaction with acetylated α-bromosugars in acetone or aqueous ac

Full text of DOI:10.1248/cpb.40.131

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