Synthesis and Testing of Quinone-Based Bis(2,2-dimethyl-1-aziridinyl)phosphinyl Carbamates as Radiation-Potentiating Antitumor Agents

Article abstract of DOI:10.1021/jm00401a028

Two new drug candidates, in which a quinonoid moiety is linked to the reactive bis(2,2-dimethyl-1-aziridinyl)phosphinyl function, have been prepared and tested in vivo for antitumor activity and in vitro as potentiators of the cytotoxic effect of X-irradi