Journal of Organic Chemistry p. 2593 - 2597 (1988)
Update date:2022-08-03
Topics:
Govindan, S. V.
Fuchs, P. L.
A two-step method for oxidation of olefins to α-diketones is presented.Tricyclic olefin 12 was converted to three stereodefined 1,2-diols 14, 15, and 16.Swern oxidation of each of these substrates gave the same enolized α-diketone 17; base-catalyzed isomerization of this material quantitatively afforded an isomerized α-diketone 7B bearing the substitution pattern found in the antileukemia agent bruceantin (1A).The four α-diketones prepared are reasonably cytotoxic against P388 mouse leukemia.
View MoreContact:+86-577-65618087-605
Address:Room 402, Unit 4 Xinhu Bldg. Waitan Ruian City, Zhejiang China.
Shijiazhuang Frontierchem Co., Ltd.
Contact:+86-311-89271196
Address:4-4-202 No.15 Biandian Street,Shijiazhuang
Changzhou Welton Chemical Co., Ltd,
Contact:0086-519-85910828,85920537,85912897
Address:No.8 Jinlong Road, Binjiang Park, Changzhou, Jiangsu, China.
Beijing Cooperate Pharmaceutical Co.,Ltd
website:http://www.cooperate-pharm.com/
Contact:86-01060279497
Address:No.507,Building 4,Tianhua Street, Biomedicine industrial Base
Contact:+8613400661290
Address:No 908,Kangwan Rd, Liuyang Economic
Doi:10.1002/jccs.200800095
(2008)Doi:10.1016/j.tetlet.2009.01.103
(2009)Doi:10.1016/j.tet.2009.01.041
(2009)Doi:10.1039/c6gc01101b
(2016)Doi:10.1016/j.tetlet.2009.02.178
(2009)Doi:10.1016/S0040-4039(00)96129-X
(1987)
