Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine

DOI: 10.1021/jm00402a024

Source and publish data:

Journal of Medicinal Chemistry p. 1392 - 1396 (1988)

Update date:2022-07-30

Topics:

Authors:

Gao Gao

Zong Zong

Campbell

Kula Kula

Baldessarini

Neumeyer

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Article abstract of DOI:10.1021/jm00402a024

The R-(-) and S-(+) enantiomers of 11-hydroxy-N-n-propylnoraporphine, (R)-3 and (S)-3, were synthesized in six steps from 1-(3-methoxy-2-nitrobenzyl)isoquinoline. Neuropharmacological evaluation of the R and S isomers (by affinity to dopamine receptor sit

Full text of DOI:10.1021/jm00402a024

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