Journal of Medicinal Chemistry p. 1363 - 1368 (1988)
Update date:2022-07-30
Topics:
Kanojia, Ramesh M.
Press, Jeffery B.
Lever, O. William
Williams, Louella
McNally, James J.
et al.
A series of isoquinolin-3-ol derivatives (II) was prepared as analogues of the clinical cardiotonic agent bemarinone (ORF 16600,I).Although in many respects the structural requirements for the cardiotonic activity of II are similarto those of bemarinone, ceratin differences between the series were noted.Our structure-activity studies show that II is less sensitive to alkoxy-substitution effects than is I, and more significantly, 4-substitution of II by alkyl groups, halogen, or alkanecarboxylic acid derivatives enhances cardiotonic activity in II in contrast to I, wherein analogous substitution eliminated activity.A linear correlation between contractile force (CF) increase and cyclic nucleotide phosphodiesterase fraction III (PDE-III) inhibition by the title compounds was determined.The isoquinoline derivatives were characteristically short-acting cardiotonic agents with good potency and selectivity.
View MoreTianjin Bright Future Technology Co., Ltd
Contact:0086-22-58016666
Address:NO.136 DongTeng Lake Street Tianjin Economic and Technology Development Area,Tainjin,China
Shandong Jusage Technology Co.,Ltd.
Contact:86-13406130167
Address:No.20,North Ride No.9 Road, Guangrao Economic Development Zone, Shandong Province
Laizhou City Laiyu Chemical CO.,Ltd
Contact:+86-535-2719337/2719339
Address:Chenggang road zhuyou laizhou City Shangdong China
Shanghai better-in Medical Technology Co.,LTD.
Contact:+86-21-38921049
Address:Lane 720 zhangjianggaoke cailun road, Pudong, Shanghai, room 513
Shanghai Longjin Metallic Material Co., Ltd.
website:http://www.shlongjin.cn/
Contact:021-56517503,56502257
Address:No.16, Lane 555, Chengyin Road, Shanghai
Doi:10.1021/ja01123a004
(1952)Doi:10.1021/om9906316
(1999)Doi:10.1016/S0040-4020(99)00805-4
(1999)Doi:10.1021/ol9908272
(1999)Doi:10.1016/S0040-4039(99)01494-X
(1999)Doi:10.1021/jo991299a
(1999)