Renal vasodilators. The role of the 4-substituent in isoquinolin-3-ol cardiovascular agents: 4-Ureido derivatives of isoquinolin-3-ol with selective renal vasodilator properties

Article abstract of DOI:10.1021/jm00125a011

The synthesis and cardiovascular evaluation of a series of isoquinolin-3-ol derivatives bearing a variety of nitrogen substituents (amino, acylamino, carbamate, and ureido) at C-4 are described. Certain of these compounds have a selective renal vasodilati