Polycyclic Aryl- and Heteroarylpiperazinyl Imides as 5-HT1A Receptor Ligands and Potential Anxiolytic Agents: Synthesis and Structure-Activity Relationship

DOI: 10.1021/jm00402a023

Source and publish data:

Journal of Medicinal Chemistry p. 1382 - 1392 (1988)

Update date:2022-07-30

Topics:

Authors:

Abou-Gharbia, Magid

Patel, Usha R.

Webb, Michael B.

Moyer, John A.

Andree, Terrance H.

Muth, Eric A.

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Article abstract of DOI:10.1021/jm00402a023

A series of polycyclic aryl- and heteroarylpiperazinyl imides were prepared and tested in various receptor-binding and behavioral tests.Parameters measured included in vitro inhibition of D₂ and 5-HT_1A receptor binding, inhibition of

Full text of DOI:10.1021/jm00402a023

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