Polycyclic Aryl- and Heteroarylpiperazinyl Imides as 5-HT1A Receptor Ligands and Potential Anxiolytic Agents: Synthesis and Structure-Activity Relationship

DOI: 10.1021/jm00402a023

Source and publish data:

Journal of Medicinal Chemistry p. 1382 - 1392 (1988)

Update date:2022-07-30

Topics:

Authors:

Abou-Gharbia, Magid

Patel, Usha R.

Webb, Michael B.

Moyer, John A.

Andree, Terrance H.

Muth, Eric A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00402a023

A series of polycyclic aryl- and heteroarylpiperazinyl imides were prepared and tested in various receptor-binding and behavioral tests.Parameters measured included in vitro inhibition of D₂ and 5-HT_1A receptor binding, inhibition of

Full text of DOI:10.1021/jm00402a023

Products guided by the article

Product name:4-{4-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-4-aza-tricyclo[5.3.2.0^2,6]dodecane-3,5-dione

Cas No:114222-60-5

R&D Labs maybe for 114222-60-5

Beijing Stable Chemcial Co.ltd

Contact:86-10-63785052

Address:A1301 Technological Edifice. No.4 FuFeng Road,FengTai District, Beijing. China
Hebei Tete Trade Co., Ltd.

Contact:86-311-83160559

Address:shijiazhuang
JiangXi Keyuan Biopharma Co., LTD.

Contact:+86-563-6833666

Address:Guangde Fine Chemical Zone, Anhui Province, China
Shanghai Harvest Chemical Ind. Co., Ltd.

Contact:021-51385350

Address:ROOM 806-807, AI LI CHEN BUILDING, No.333 JINGXIANG ROAD, PUDONG DISTRICT, 201206, SHANGHAI
Shanghai united Scientific Co.,Ltd.

Contact:+86-21-53535353

Address:28F No.900 huaihai Road Shanghai China

Relevant to this article

Building molecular complexity via tandem ru-catalyzed isomerization/C-H activation

Doi:10.1021/ol900243x
(2009)
Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases

Doi:10.1016/j.bmcl.2008.12.074
(2009)
Retention of stereochemistry in the microwave assisted synthesis of 1H-tetrazole bioisosteric moiety from chiral phenyl-acetic acid derivatives

Doi:10.1016/j.tetlet.2013.09.022
(2013)
Unexpected Z/E isomerism of N-methyl-O-phosphothioyl benzohydroxamic acids, their oxyphilic reactivity and inertness to amines

Doi:10.1007/s11224-020-01719-1
(2021)
Cleavage of siloxanes with organyltrifluoro- and diorganyldifluorosilanes

Doi:10.1016/0022-328X(92)80125-H
(1992)
An improved and practical procedure for the synthesis of substituted phenylacetylpyridines

Doi:10.1016/S0040-4039(98)00140-3
(1998)

Article Doi