Polycyclic Aryl- and Heteroarylpiperazinyl Imides as 5-HT1A Receptor Ligands and Potential Anxiolytic Agents: Synthesis and Structure-Activity Relationship

DOI: 10.1021/jm00402a023

Source and publish data:

Journal of Medicinal Chemistry p. 1382 - 1392 (1988)

Update date:2022-07-30

Topics:

Authors:

Abou-Gharbia, Magid

Patel, Usha R.

Webb, Michael B.

Moyer, John A.

Andree, Terrance H.

Muth, Eric A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00402a023

A series of polycyclic aryl- and heteroarylpiperazinyl imides were prepared and tested in various receptor-binding and behavioral tests.Parameters measured included in vitro inhibition of D₂ and 5-HT_1A receptor binding, inhibition of

Full text of DOI:10.1021/jm00402a023

Products guided by the article

Product name:4-{4-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-4-aza-tricyclo[5.3.2.0^2,6]dodecane-3,5-dione

Cas No:114222-60-5

R&D Labs maybe for 114222-60-5

Suzhou Credit International Trading Co., Ltd

Contact:+86-512-65398039

Address:Qingdeng, Hightech. District, Suzhou
SuZhou Hua-Emy Chemical Import and Export Co., LTD.

Contact:+86-512-88804994; +86-512-88804550;

Address:710, Building B, International Trade Center, 12 Huanghelu, Changshu, Jiangsu,China
YanCheng LongShen Chemical Co.,Ltd.

Contact:+86-515-86668866

Address:No.13,Weiyi Road,Funing Aoyang Industrial Park
Lonzeal Pharmaceuticals Co., Ltd.

website:http://www.lonzeal.com

Contact:+86-13381011962

Address:RM 801, Yue MOMA, No. 26 Anningzhuang Rd. Haidian District, Beijing, China
Sigma-Aldrich Chemie GmbH

website:http://www.sigmaaldrich.com

Contact:800 558-9160

Address:Industriestrasse 25CH-9471 Buchs SGSwitzerland

Relevant to this article

Building molecular complexity via tandem ru-catalyzed isomerization/C-H activation

Doi:10.1021/ol900243x
(2009)
Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases

Doi:10.1016/j.bmcl.2008.12.074
(2009)
Retention of stereochemistry in the microwave assisted synthesis of 1H-tetrazole bioisosteric moiety from chiral phenyl-acetic acid derivatives

Doi:10.1016/j.tetlet.2013.09.022
(2013)
Unexpected Z/E isomerism of N-methyl-O-phosphothioyl benzohydroxamic acids, their oxyphilic reactivity and inertness to amines

Doi:10.1007/s11224-020-01719-1
(2021)
Cleavage of siloxanes with organyltrifluoro- and diorganyldifluorosilanes

Doi:10.1016/0022-328X(92)80125-H
(1992)
An improved and practical procedure for the synthesis of substituted phenylacetylpyridines

Doi:10.1016/S0040-4039(98)00140-3
(1998)

Article Doi