Ortho-Selective Alkylation of Phenols with Symmetric Sulfides and Sulfuryl Chloride

Article abstract of DOI:10.1246/bcsj.60.4184

Sulfuryl chloride has been shown to be useful activator for sulfides in the selective preparation of ortho-alkylated phenols via <2,3>sigmatropic rearrangement.By this process, ortho-alkylated phenols have been prepared with various symmetric sulfides in good yields.The rearrangement products having 3-chloropropyl or 3-methyl-3-butenyl moiety have been converted into 2H-1-benzopyran derivatives.