1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV. Part 1

DOI: 10.1016/j.bmcl.2009.01.009

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1075 - 1079 (2009)

Update date:2022-07-29

Topics:

Authors:

Barber, Christopher G.

Blakemore, David C.

Chiva, Jean-Yves

Eastwood, Rachel L.

Middleton, Donald S.

Paradowski, Kerry A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.bmcl.2009.01.009

The development of a new class of CCR5 antagonist replacing the tropane core of maraviroc by piperidine with a branched N-substituent is described. Compound 15h shows good whole cell antiviral activity together with microsomal stability and only weak activity at the hERG ion channel.

Full text of DOI:10.1016/j.bmcl.2009.01.009

Products guided by the article

Product name:C₃₀H₄₀Cl₂N₄O₂

Cas No:1141497-33-7

R&D Labs maybe for 1141497-33-7

Baoding City Light Industry And Textiles Imp.& Exp. Corp. Chemical Department.

Contact:86-312-3262436

Address:NO.658 CHAOYANG SOUTH STREET,BAODING CITY HEBEI CHINA
Shanghai Yuking Water Soluble Material Tech Co., Ltd

Contact:86-21-68286299

Address:4F, 13B, No. 600, South Xinyuan Road 201306, Shanghai, China
Jiangsu Zhenfang Chemical CO.,LTD.(Suzhou Zhenfang Chemical Factory)

Contact:+86-512-69598882

Address:Room1201, Jiayuan Road No.1018, Xiangcheng District, Suzhou, China
Shandong Bolode Bio-Technology Co., LTD

Contact:+86-0531-58966870

Address:136 Jingyi Road,Huaiyin District,Jinan,Shandong,China
PINGYUAN SIHUAN PHARMACEUTICAL CO., LTD

Contact:+86-531-55696072

Address:#2766,yinxiu Road, Economic Development Zone, Pingyuan Country, Shandong Province, China.

Relevant to this article

Silylation-Mediated Oxidation of 4-Aza-3-ketosteroids with DDQ Proceeds via DDQ-Substrate Adducts

Doi:10.1021/ja00218a062
(1988)
Lewis acid induced rearrangement of 2,3-epoxy sulfides; regiospecific trapping of thiiranium ion intermediates with nitrogen heterocycles and amides. Use of imines as nucleophilic equivalents for the selective monoalkylation of primary amines

Doi:10.1016/0040-4020(96)00036-1
(1996)
Synthesis and biological properties of iron chelators based on a bis-2-(2-hydroxy-phenyl)-thiazole-4-carboxamide or -thiocarboxamide (BHPTC) scaffold

Doi:10.1016/j.bmc.2009.11.057
(2010)
Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys

Doi:10.1111/bph.14874
(2020)
Enantioselective cyanation of aldehydes catalyzed by bifunctional salen-aluminum complex

Doi:10.1016/j.catcom.2012.06.025
(2012)
Total synthesis of (±)-maistemonine, (±)-stemonamide, and (±)-isomaistemonine

Doi:10.1021/jo202042x
(2011)

Article Doi