Allosteric modulators of the adenosine A1 receptor: Synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes

Article abstract of DOI:10.1021/jm9002582

A series of 4-substituted 2-amino-3-benzoylthiophenes was screened using a functional assay of A1ARmediated phosphorylation of ERK1/2 in intact CHO cells to identify both potential agonistic effects as well the ability to allosterically modulate the activ