Prevention of Diketopiperazine Formation in Peptide Synthesis by a Simultaneous Deprotection-Coupling Procedure: Entrapment of Reactive Nucleophilic Species by in situ Acylation

DOI: 10.1039/c39870001155

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Journal of the Chemical Society. Chemical communications p. 1155 - 1156 (1987)

Update date:2022-08-03

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Authors:

Shute, Richard E.

Rich, Daniel H.

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Article abstract of DOI:10.1039/c39870001155

Hydrogenolysis of Z-amino acid-D-Pro-OMe dipeptides in the presence of acetic acid results, almost quantitatively, in the formation of diketopiperazines, whereas in the presence of Boc- or 2-(trimethylsilyl)ethoxycarbonyl protected amino acid pentafluorop

Full text of DOI:10.1039/c39870001155

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