Prevention of Diketopiperazine Formation in Peptide Synthesis by a Simultaneous Deprotection-Coupling Procedure: Entrapment of Reactive Nucleophilic Species by in situ Acylation

DOI: 10.1039/c39870001155

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1155 - 1156 (1987)

Update date:2022-08-03

Topics:

Authors:

Shute, Richard E.

Rich, Daniel H.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39870001155

Hydrogenolysis of Z-amino acid-D-Pro-OMe dipeptides in the presence of acetic acid results, almost quantitatively, in the formation of diketopiperazines, whereas in the presence of Boc- or 2-(trimethylsilyl)ethoxycarbonyl protected amino acid pentafluorop

Full text of DOI:10.1039/c39870001155

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:(R)-2-(2-Trimethylsilanyl-ethoxycarbonylamino)-propionic acid pentafluorophenyl ester

Cas No:114658-23-0

R&D Labs maybe for 114658-23-0

Hawks Chemical

Contact:+44 (0)161 367 9441

Address:
Shanghai Gsyn Chemical Co.,Ltd.

Contact:86-021-67158290

Address:86-021-67158291
JIANGSU GRAND XINYI PHARMACEUTICAL CO.,LTD

website:http://www.xypharm.com/

Contact:+86-515-84383317

Address:Chenli Road,Costal Chemical Area Binhai,Yancheng, Jiangsu,China
Tradlon Chemical Co., Ltd.

Contact:+86-710-3516804

Address:Number 83,Panggong road,Xiangcheng District,Xiangyang ,Hubei
Shanghai Forever Synthesis Co.,Ltd.

Contact:021-61124658

Address:Zhoukang Road,Pudong New District,Shanghai,China

Relevant to this article

Selective C-H activation of haloalkanes using a rhodiumtrispyrazolylborate complex

Doi:10.1021/ja9002316
(2009)
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases

Doi:10.1021/jm801529c
(2009)
Aluminium-catalysed isocyanate trimerization, enhanced by exploiting a dynamic coordination sphere

Doi:10.1039/c9cc03339d
(2019)
A very efficient route toward the 4a-methyltetrahydrofluorene skeleton: short synthesis of (±)-dichroanone and (±)-taiwaniaquinone H

Doi:10.1021/jo900153y
(2009)
A biomimetic approach to the Elaeocarpus alkaloids. Syntheses of (±)-Elaeokanine A, (±)-Elaeokanine C, (±)-Elaeocarpidine, and (±)-Tarennine

Doi:10.1021/jo00249a008
(1988)
13C Nuclear Magnetic Resonance Study on the Nature of Resonance Interactions in 4-Substituted Benzonitriles, Acetophenones, and Methyl Benzoates

Doi:10.1021/jo00250a028
(1988)

Article Doi