Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing

Article abstract of DOI:10.1016/j.bioorg.2019.01.066

The inhibition of steroidogenic cytochrome P450 enzymes has been shown to play a central role in the management of life-threatening diseases such as cancer, and indeed potent inhibitors of CYP19 (aromatase) and CYP17 (17α hydroxylase/17,20 lyase) are curr