Synthesis of N-protected O-hydroxyl-phenyl-α-aminophosphonic monoester

Article abstract of DOI:10.1080/10426500701796579

A series of N-protected O-hydroxylphenyl α-aminophosphonic monoesters were synthesized via three-component Mannich-type reactions of phosphoramides, aldehydes (ketones) and 2-chlorobenzo [1,3,2] dioxaphospholes under solvent free and catalyst-free conditions, followed by hydrolysis. It is an efficient and green method to the synthesis of N-phosphoramino O-hydroxyphenyl 1-aminoalkylphosphonic monoesters with high yields. Copyright Taylor & Francis Group, LLC.