Enantiomers of 7-(2,3-Epoxypropoxy)actinomycin D as Dual-Action DNA-Acting Antitumor Agents

DOI: 10.1021/jm00403a010

Source and publish data:

Journal of Medicinal Chemistry p. 1540 - 1547 (1988)

Update date:2022-08-05

Topics:

Authors:

Sengupta, Sisir K.

Rosenbaum, David P.

Sehgal, Raj K.

Almassian, Bijan

Blondin, Joanne

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00403a010

Enantiomeric forms of (+/-)-EPA have been synthesized; these are (R)-(+)- and (S)-(-)-EPA, which are active against a range of actinomycin resistant and marginally resposive tumors.The (R)-(+) enantiomer is unif

Full text of DOI:10.1021/jm00403a010

Products guided by the article

Product name:Toluene-4-sulfonic acid (R)-3-(8-amino-1,9-bis-dimethylcarbamoyl-4,6-dimethyl-7-oxo-7H-phenoxazin-3-yloxy)-2-hydroxy-propyl ester

Cas No:114715-26-3

R&D Labs maybe for 114715-26-3

Xuzhou Tianrun Chemical Co.,Ltd

website:http://www.tianrunchem.cn

Contact:86-516-83832636

Address:fuxing road
Suzhou BEC Fine Chemicals Co., Ltd.

website:http://www.bek.com.cn

Contact:0512-68095917　 18913193865

Address:6, Jin Shan Road, Suzhou New District, 215011 China Suzhou Nations Pharmaceutical Innovation Center Inside
Guangxi Nanning Guangtai Agriculture Chemical Co.,Ltd

Contact:+86-771-2311266

Address:Room703,Building12, Software Park Phase II,NO.68,Keyuan Road,Nanning City,Guangxi,China
Weinan Rigel Pharm Co., Ltd.

Contact:+86-913-2223392

Address:No. 32, Xinanjing Road, Weinan City, Shaanxi Province, 714000, China
Anhui Redstar Pharmaceutical Corp., Ltd

Contact:+86-563-5120837

Address:Jingxian Industrial Development Zone, Anhui , China

Relevant to this article

Concise SAR Exploration Based on the "head-to-Tail" Approach: Discovery of PI4KIIIα Inhibitors Bearing Diverse Scaffolds

Doi:10.1021/acsmedchemlett.6b00232
(2016)
Spectroscopic and electrochemical characterization of solutions and films of a new redox couple: Co(II)/Co(III) N-confused porphyrin

Doi:10.1016/j.inoche.2004.09.020
(2004)
On-water magnetic NiFe₂O₄ nanoparticle-catalyzed Michael additions of active methylene compounds, aromatic/aliphatic amines, alcohols and thiols to conjugated alkenes

Doi:10.1039/c6ra21160g
(2016)
Benzoic hydroxamate-based iron complexes as model compounds for humic substances: Synthesis, characterization and algal growth experiments

Doi:10.1039/c5ra25256c
(2016)
CONVERSION OF UBIQUINONE-9 TO UBIQUINONE-10 BY USE OF THE WITTIG REACTION

Doi:10.1007/BF00958351
(1987)
Synthesis of a Structurally Modified Glycal. (-)-(2R,4S)-2-Methyl-2-vinyl-4-(benzyloxy)-3,4-dihydro-2H-pyran

Doi:10.1021/jo00248a010
(1988)

Article Doi