Enantiomers of 7-(2,3-Epoxypropoxy)actinomycin D as Dual-Action DNA-Acting Antitumor Agents

DOI: 10.1021/jm00403a010

Source and publish data:

Journal of Medicinal Chemistry p. 1540 - 1547 (1988)

Update date:2022-08-05

Topics:

Authors:

Sengupta, Sisir K.

Rosenbaum, David P.

Sehgal, Raj K.

Almassian, Bijan

Blondin, Joanne

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Article abstract of DOI:10.1021/jm00403a010

Enantiomeric forms of (+/-)-EPA have been synthesized; these are (R)-(+)- and (S)-(-)-EPA, which are active against a range of actinomycin resistant and marginally resposive tumors.The (R)-(+) enantiomer is unif

Full text of DOI:10.1021/jm00403a010

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