Enantioselectivity of muscarinic antagonists. 2,2-dicyclohexyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodides and related 3-oxides

DOI: 10.1021/jm00117a006

Source and publish data:

Journal of Medicinal Chemistry p. 1698 - 1702 (1988)

Update date:2022-08-02

Topics:

Authors:

Romanelli

Teodori Teodori

Gualtieri

Angeli Angeli

Brasili Brasili

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Article abstract of DOI:10.1021/jm00117a006

The enantiomers of three chiral muscarinic antagonists carrying a 1,3-oxathiolane nucleus were prepared and their absolute configuration established. The enantioselectivity and tissue selectivity of such compounds were studied on rat bladder and guinea pi

Full text of DOI:10.1021/jm00117a006

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Product name:(R)-(-)-2,2-dicyclohexyl-5-(N,N-dimethylcarbamoyl)-1,3-oxathiolane

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