European Journal of Medicinal Chemistry p. 1638 - 1643 (2009)
Update date:2022-07-30
Topics:
Wang, Yubin
Zhang, Huibin
Huang, Wenlong
Kong, Jing
Zhou, Jinpei
Zhang, Beibei
Fourteen new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been synthesized, and three of them were enantiomerically pure. All the new compounds were evaluated for their activity to inhibit cholesterol absorption in rats, and most of them showed comparable effects in lowering the levels of total cholesterol in the serum.
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