Synthesis of Sulfur-Containing Analogues of Bestatin. Inhibition of Aminopeptidases by α-Thiolbestatin Analogues

Article abstract of DOI:10.1021/jm00119a022

Sulfur-containing amino acid and peptide analogues of bestatin <((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-L-leucine> (1) have been synthesized and evaluated as inhibitors of aminopeptidase M (AP-M), leucine aminopeptidase (LAP), and aminopeptidase B (A