Journal of Medicinal Chemistry p. 624 - 628 (1991)
Update date:2022-08-03
Topics:
Lowe III
Archer
Chapin
Cheng
Helweg
Johnson
Koe
Lebel
Moore
Nielsen
Russo
Shirley
A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase enzyme (CaIPDE). In vivo testing showed that this in vitro activity translates to animal models p
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