Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase

DOI: 10.1021/jm00106a024

Source and publish data:

Journal of Medicinal Chemistry p. 624 - 628 (1991)

Update date:2022-08-03

Topics:

Authors:

Lowe III

Archer Archer

Chapin Chapin

Cheng Cheng

Helweg Helweg

Johnson Johnson

Koe Koe

Lebel Lebel

Moore Moore

Nielsen Nielsen

Russo Russo

Shirley Shirley

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00106a024

A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase enzyme (CaIPDE). In vivo testing showed that this in vitro activity translates to animal models p

Full text of DOI:10.1021/jm00106a024

Products guided by the article

Product name:3-(3-Cyclopentylmethyl-2,4-dioxo-3,4-dihydro-2H-pyrido[2,3-d]pyrimidin-1-yl)-benzoic acid methyl ester

Cas No:114918-31-9

R&D Labs maybe for 114918-31-9

Hubei anhuang chemical Co.Ltd

Contact:

Address:308# dongwu avenue dongxihu district wuhan city
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

website:http://www.shydtec.com

Contact:86-21-57721279

Address:Science and Technology Park, Songjiang District, Shanghai, China
BrightGene Bio-Medical Technology Co., Ltd.

website:https://en.bright-gene.com/

Contact:+86-512-62551801

Address:Building C25 - C31, No. 218 Xinghu Road, Suzhou Industrial Park, Suzhou, Jiangsu, China.
Hangzhou Haichem Co.,Ltd.

Contact:+86-571-86025531 / 86024803

Address:1218-24 Guangyin Mansion,42 Fengqi East Road
Wuhan Shangrisyn chemicals Technology Co.,Ltd(expird)

Contact:+86-027-84466317 __ +86-15387123698

Address:wuhan - china

Relevant to this article

Fluorescent-fipronil: Design and synthesis of a stable conjugate

Doi:10.1016/j.bmcl.2018.06.036
(2018)
Antitubercular Activity and Synergistic Study of Novel Pyrazole Derivatives

Doi:10.1002/jhet.3198
(2018)
First synthesis of 5-(1-ethoxyethoxy)-N-methyl-N-phenylthiophen-2-amine and its unexpected alcoholysis

Doi:10.1134/S1070428009060244
(2009)
ETHYL 4-THIOCYANATO-3-OXO-2-ARYLHYDRAZONO-1-BUTANOATES IN HETEROCYCLIZATION REACTIONS. 2. SYNTHESIS AND STRUCTURE OF 2-IMINO-5-<1-(ARYLHYDRAZONO)-2-ETHOXYOXALYL>-4,5-DEHYDRO-1,3-OXATHIOLANES AND 2-CHLORO-4-<1-(ARYLHYDRAZONO)-2-ETHOXYOXALYL>-1,3-THIAZOLES

Doi:10.1007/BF00962756
(1988)
Formation of Cyclobutanones by the Photolytic Reaction of (CO)5Cr=C(OMe)Me with Electron-Rich Olefins

Doi:10.1021/ja00188a076
(1989)
Role of pyridine nitrogen in palladium-catalyzed imine hydrolysis: A Case Study of (E)-1-(3-bromothiophen-2-yl)-N-(4-methylpyridin-2-yl)methanimine

Doi:10.3390/molecules24142609
(2019)

Article Doi