Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase

DOI: 10.1021/jm00106a024

Source and publish data:

Journal of Medicinal Chemistry p. 624 - 628 (1991)

Update date:2022-08-03

Topics:

Authors:

Lowe III

Archer Archer

Chapin Chapin

Cheng Cheng

Helweg Helweg

Johnson Johnson

Koe Koe

Lebel Lebel

Moore Moore

Nielsen Nielsen

Russo Russo

Shirley Shirley

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Article abstract of DOI:10.1021/jm00106a024

A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase enzyme (CaIPDE). In vivo testing showed that this in vitro activity translates to animal models p

Full text of DOI:10.1021/jm00106a024

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