The preparation of substituted hydroxyphenyl-pyridyl-ethanols and α-hydroxyphenyl-α-methylpyridineethanols by the condensation of 2-, 3-, or 4-picolyllithium with select hydroxy-benzaldehydes and 4-hydroxyacetophenone

Article abstract of DOI:10.1080/00397919508011427

2-, 3-, or 4-Picolyllithium was prepared in excess lithium diisopropylamide and condensed with several hydroxy-benzaldehydes and 4-hydroxy-acetophenone to afford substituted hydroxyphenyl-pyridyl-ethanols and α-hydroxyphenyl-α-methylpyridineethanols. In two instances, 3-picolyllithium condensed with aldehydes to presumably form the hydroxyphenyl-pyridyl-ethanol, which underwent linear dehydration to the substituted pyridyl-ethylenyl-phenol.

Full text of DOI:10.1080/00397919508011427

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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The Preparation of
Substituted Hydroxyphenyl-
pyridyl-ethanols and
α-Hydroxyphenyl-α-
methylpyridineethanols by
the Condensation of 2-, 3-, or
4-Picolyllithium with Select
Hydroxy-benzaldehydes and 4-
Hydroxyacetophenone
Madlene U. Koller a , Katrina L. Peariso a , Tina S.
Guion a , Shannon Studer Martinez a & Charles F.
Beam a
a Department of Chemistry , College of Charleston
Charleston , South Carolina, 29424
Published online: 16 Feb 2007.
To cite this article: Madlene U. Koller , Katrina L. Peariso , Tina S. Guion ,
Shannon Studer Martinez & Charles F. Beam (1995) The Preparation of Substituted
Hydroxyphenyl-pyridyl-ethanols and α-Hydroxyphenyl-α-methylpyridineethanols by
the Condensation of 2-, 3-, or 4-Picolyllithium with Select Hydroxy-benzaldehydes
and 4-Hydroxyacetophenone, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 25:19, 2963-2974, DOI:
10.1080/00397919508011427

To link to this article: http://dx.doi.org/10.1080/00397919508011427
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