178. Alkylation of Imidazolidinone Dipeptide Derivatives: Preparation of Enantiomerically Pure Di- and Tripeptides by "Chirality Transfer" via a Pivalaldehyde N,N-Acetal Center

Article abstract of DOI:10.1002/hlca.19870700727

Glycylglycine, glycyl-(S)-alanine, and (S)-alanylglycine esters are cyclized through pivalaldehyde imines to give dipeptide-derived 3-(benzyloxycarbonyl)-2-(tert-butyl)-5-oxoimidazolidine-1-acetates 1-3.These are alkylated diastereoselecively by Li-enolat