178. Alkylation of Imidazolidinone Dipeptide Derivatives: Preparation of Enantiomerically Pure Di- and Tripeptides by "Chirality Transfer" via a Pivalaldehyde N,N-Acetal Center

DOI: 10.1002/hlca.19870700727

Source and publish data:

Helvetica Chimica Acta p. 1930 - 1936 (1987)

Update date:2022-09-26

Topics:

Authors:

Polt, Robin

Seebach, Dieter

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/hlca.19870700727

Glycylglycine, glycyl-(S)-alanine, and (S)-alanylglycine esters are cyclized through pivalaldehyde imines to give dipeptide-derived 3-(benzyloxycarbonyl)-2-(tert-butyl)-5-oxoimidazolidine-1-acetates 1-3.These are alkylated diastereoselecively by Li-enolat

Full text of DOI:10.1002/hlca.19870700727

Products guided by the article

Product name:(2R,5S)-2-tert-Butyl-3-methoxycarbonylmethyl-5-methyl-4-oxo-imidazolidine-1-carboxylic acid benzyl ester

Cas No:115572-71-9

R&D Labs maybe for 115572-71-9

Suzhou ATL Chemical Co.,ltd

Contact:+86-0512-69209969

Address:Room 317,Lushan Road,Suzhou New District,Jiangsu Province,China.
Ningbo Hi-tech Zone Nice-Synth Chemical Industry Ltd.

Contact:+86-(574)-81110986

Address:No. 1210, Building 3, Wante Business Centre, Hi-tech Zone, Ningbo
Jinan Hongfangde Pharmatech Co.LTD

Contact:0531-88870908

Address:F Bldg,750#,Shunhua Rd,New&High-tech Zone,Jinan,Shandong,China 250101
Exploiter Molybdenum Co.,Ltd

Contact:86-379-63338609

Address:Jiudian Village,Deting Town,Song County,Luoyang
Suzhou HeChuang Chemical Co.,Ltd.

Contact:+86-512-88800520

Address:No.9 Guanchao Rd,Changshu Advanced Materials Industy Park

Relevant to this article

Role of Fe(IV)-oxo intermediates in stoichiometric and catalytic oxidations mediated by iron pyridine-azamacrocycles

Doi:10.1021/ic202435r
(2012)
Synthesis of diversely functionalised 2,2-disubstituted oxetanes: Fragment motifs in new chemical space

Doi:10.1039/c5cc05740j
(2015)
Preparation and in vitro evaluation of benzylsulfanyl benzoxazole derivatives as potential antituberculosis agents

Doi:10.1016/j.ejmech.2008.06.027
(2009)
Synthesis and biological evaluation of some new pyrazoline substituted benzenesulfonylurea/thiourea derivatives as anti-hyperglycaemic agents and aldose reductase inhibitors

Doi:10.1016/j.ejmech.2014.04.046
(2014)
Inhibitors of the cysteine synthase CysM with antibacterial potency against dormant mycobacterium tuberculosis

Doi:10.1021/acs.jmedchem.6b00674
(2016)
New synthetic strategies for the stereocontrolled synthesis of substituted 'skipped' diepoxides

Doi:10.1016/j.tet.2009.05.074
(2009)

Article Doi