178. Alkylation of Imidazolidinone Dipeptide Derivatives: Preparation of Enantiomerically Pure Di- and Tripeptides by "Chirality Transfer" via a Pivalaldehyde N,N-Acetal Center

DOI: 10.1002/hlca.19870700727

Source and publish data:

Helvetica Chimica Acta p. 1930 - 1936 (1987)

Update date:2022-09-26

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Authors:

Polt, Robin

Seebach, Dieter

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Article abstract of DOI:10.1002/hlca.19870700727

Glycylglycine, glycyl-(S)-alanine, and (S)-alanylglycine esters are cyclized through pivalaldehyde imines to give dipeptide-derived 3-(benzyloxycarbonyl)-2-(tert-butyl)-5-oxoimidazolidine-1-acetates 1-3.These are alkylated diastereoselecively by Li-enolat

Full text of DOI:10.1002/hlca.19870700727

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