Novel large-ring 1,3-bridged 2-azetidinones as potential inhibitors of penicillin-binding proteins

Article abstract of DOI:10.1002/ejoc.200801193

Novel bicyclic 2-azetidinones, in which the β-laclam moiety is embedded in a 1,3-bridging large ring, have been studied experimentally and theoretically. The compounds were prepared from (3S,4R)-3-[(1R)-1-(tert- butyldimethylsilyloxy)- ethyl]-4-propyl-2-a