A novel route for chiral synthesis of the triazole antifungal ER-30346

DOI: 10.1248/cpb.46.1125

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1125 - 1129 (1998)

Update date:2022-09-26

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Authors:

Kaku, Yumiko

Tsuruoka, Akihiko

Kakinuma, Hiroyuki

Tsukada, Itaru

Yanagisawa, Manabu

Naito, Toshihiko

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Article abstract of DOI:10.1248/cpb.46.1125

A novel synthetic route to (2S,3S)-2-(2,4-difluorophenyl)-3-hydroxy-2- methyl-4-(1-(1,2,4-triazolyl))butyronitrile (2), an intermediate for the orally active triazole antifungal agent ER-30346, was developed from methyl S-(+)-3-hydroxy-2-methylpropionate,

Full text of DOI:10.1248/cpb.46.1125

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