Synthesis of 8-Substituted Derivatives of the 2-Deoxy Analogue of 3-Deoxy-β-D-manno-2-octulopyranosonic Acid (2-Deoxy-β-KDO) as Inhibitors of 3-Deoxy-D-manno-octulosonate Cytidylyltransferase

Article abstract of DOI:10.1021/jm00125a023

The 2-deoxy analogue of 3-deoxy-β-D-manno-2-octulopyranosonic acid (2-deoxy-β-KDO, 2) is a potent inhibitor of the enzyme 3-deoxy-D-manno-octulosonate cytidylyltransferase, which is involved in the biosynthesis of lipopolysaccharide, an essential componen