
Journal of the Chemical Society. Chemical communications p. 1797 - 1798 (1987)
Update date:2022-08-03
Topics:
Jones, David W.
Thompson, Adrian M.
The 2-benzopyran-3-one (7) is a stable, isolable, and useful Diels-Alder diene; its adduct (10) formed with dimethyl fumarate is transformed in three steps into methyl epipodophyllate (14) which gives epipodophyllotoxin (2) (81percent) by direct lactonisation (ZnCl2-tetrahydrofuran-4 Angstroem molecular sieves).
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