Synthesis of Methyl 2-(Methyltrifluoroacetylamino)-3-(trimethylsiloxy)alkanoates and N-Methyl-N-trifluoroacetyldidehydroamino Acid Methyl Esters

DOI: 10.1055/s-1988-27487

Source and publish data:

Synthesis p. 127 - 129 (1988)

Update date:2022-07-29

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Authors:

Simchen, Gerhard

Schulz, Dieter

Seethaler, Toni

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Article abstract of DOI:10.1055/s-1988-27487

Reaction of aliphatic and aromatic aldehydes 4 with the ketene acetal 3 in presence of Lewis acid 2 or zinc bromide affords methyl 2-(methyltrifluoroacetylamino)-3-(trimethylsiloxy)alkanoates 5.By elimination of trimethylsilanol from 5 by means of methane

Full text of DOI:10.1055/s-1988-27487

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