EINE NEUE SYNTHESE VON VINBLASTIN-DERIVATEN III. SYNTHESE UND REAKTIONEN VON 21,Nb-SECO-CLEAVAMIN-DERIVATEN ALS VORLAUFER ZU 20'-DEETHYL-20'-DEOXYVINBLASTIN UND (+/-)-16α-METHOXYCARBONYL-20-DEETHYL-15,20-DIHYDROCLEAVAMIN

Article abstract of DOI:10.1016/S0040-4020(01)86862-9

In a new concept for the synthesis of 20'-deethyl-20'deoxyvinblastine, Nb-seco-cleavamine derivatives 1a,2a are possible precursors.For the synthesis of these compounds the indolizino<5,4-b> indoles 8I,II were treated with benzyl chloroformate/aq. sodium