Synthesis of polysubstituted 1,2-dihydroisoquinolines via a CuI-catalyzed arylation/condensation cascade process

DOI: 10.1016/j.tetlet.2009.03.159

Source and publish data:

Tetrahedron Letters p. 3683 - 3685 (2009)

Update date:2022-08-03

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Authors:

Wu, Yangyang

Zhang, Yihua

Jiang, Yongwen

Ma, Dawei

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Article abstract of DOI:10.1016/j.tetlet.2009.03.159

CuI-catalyzed reaction of 1-(2-bromophenyl)-propargylamines 4 with β-keto esters in i-PrOH/H₂O (3:1) at 50 °C provides polysubstituted 1,2-dihydroisoquinolines. The transformation involves a cascade intermolecular C-C bond formation and intramo

Full text of DOI:10.1016/j.tetlet.2009.03.159

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