Design and Synthesis of Propranolol Analogues as Serotonergic Agents

DOI: 10.1021/jm00124a021

Source and publish data:

Journal of Medicinal Chemistry p. 859 - 863 (1989)

Update date:2022-07-30

Topics:

Authors:

Pierson, M. Edward

Lyon, Robert A.

Titeler, Milt

Kowalski, Paul

Glennon, Richard A.

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Article abstract of DOI:10.1021/jm00124a021

Serotonin (5-HT) binds with nearly identical affinity at the various central 5-HT binding sites.Few agents bind with selectivity for 5-HT_1A sites.The β-adrenergic antagonist propranolol binds stereoselectively both at 5-HT_1A and 5-HT

Full text of DOI:10.1021/jm00124a021

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