Selective Alkylation of Ketones with a Bulky Aluminum Reagent-the THF-TBSOTf System

DOI: 10.1055/s-1997-792

Source and publish data:

Synlett p. 357 - 358 (1997)

Update date:2022-07-29

Topics:

Authors:

Saito, Susumu

Ito, Masahiro

Maruoka, Keiji

Yamamoto, Hisashi

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Article abstract of DOI:10.1055/s-1997-792

Various ketones can be alkylated with tetrahydrofuran (THF) to provide α-siloxybutylated ketones in the presence of a bulky aluminum reagent, lithium diisopropylamide (LDA), and t-butyldimethylsilyl triflate (TBSOTf).

Full text of DOI:10.1055/s-1997-792

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