Marine Drugs p. 2054 - 2068 (2013)
Update date:2022-08-05
Topics:
Zheng, Cai-Juan
Shao, Chang-Lun
Wu, Lu-Yong
Chen, Min
Wang, Kai-Ling
Zhao, Dong-Lin
Sun, Xue-Ping
Chen, Guang-Ying
Wang, Chang-Yun
One new phenylalanine derivative 4′-OMe-asperphenamate (1), along with one known phenylalanine derivative (2) and two new cytochalasins, aspochalasin A1 (3) and cytochalasin Z24 (4), as well as eight known cytochalasin analogues (5-12) were isolated from the fermentation broth of Aspergillus elegans ZJ-2008010, a fungus obtained from a soft coral Sarcophyton sp. collected from the South China Sea. Their structures and the relative configurations were elucidated using comprehensive spectroscopic methods. The absolute configuration of 1 was determined by chemical synthesis and Marfey's method. All isolated metabolites (1-12) were evaluated for their antifouling and antibacterial activities. Cytochalasins 5, 6, 8 and 9 showed strong antifouling activity against the larval settlement of the barnacle Balanus amphitrite, with the EC50 values ranging from 6.2 to 37 μM. This is the first report of antifouling activity for this class of metabolites. Additionally, 8 exhibited a broad spectrum of antibacterial activity, especially against four pathogenic bacteria Staphylococcus albus, S. aureus, Escherichia coli and Bacillus cereus.
View MoreContact:021-61840961 021-61840962
Address:No.157,Zhuguang Rd, Qingpu, Shanghai, China
Jiangsu Dacheng Pharmaceutical and Chemical Co.,Ltd
Contact:+86-0517-87036900
Address:Chuzhou Chemical park, Huai'an, Jiangsu Province
Huaian Double Win Chemicals Co.,Ltd.
Contact:+86-13511538872
Address:Blk 43,Greenland Century Town,Huaian District, Huaian City,Jiangsu Province,China
hangzhou verychem science and technology co.ltd
website:http://www.verypharm.com
Contact:+86-571-88162785; 88162786
Address:F1502, 753 Shenhua road, Hangzhou, China
Jintan City Mego Chemical Co., Ltd
Contact:+86-0519-82814387
Address:23# Dengguan Town, Jintan, Jiangsu Province, China
Doi:10.1002/anie.201006422
(2011)Doi:10.1016/j.bmc.2009.04.055
(2009)Doi:10.1016/j.bmc.2009.04.069
(2009)Doi:10.1007/s11164-015-1987-4
(2015)Doi:10.1016/j.tet.2009.05.007
(2009)Doi:10.1021/jm900460z
(2009)