METAL-DIRECTED ASYMMETRIC SYNTHESIS OF DIASTEREOISOMERIC β-PHENYL SERINES USING (+)-KETOPINIC ACID AS A CHIRAL AUXILIARY.

Article abstract of DOI:10.1016/S0040-4039(00)87836-3

A new method for the asymmetric synthesis of threo and erythro β-phenylserines using (+)-ketopinic acid as a chiral auxiliary is reported.The reaction was based on the condensation of benzaldehyde with the metal (Li⁺, K⁺ or Zn⁺⁺ ) enolates of the chiral imines 3.