6
also examined. The desired product 3j was obtained with a yield of 80% (Scheme 4).
Conclusions
In conclusion, we have developed a green and practical method for the synthesis of N-arylsulfonamides from easily available
chloramine salts and arylboronic acids. In this process, the chloramine salt is assumed to serve as an electrophile to oxidize the
copper catalyst through oxidative addition. Importantly, this reaction can be performed on a gram scale under mild conditions,
which is important to industry applications. Further exploration based on this new method for the synthesis of well-known bioactive
N-arylsulfonamides in a convenient and economical manner is ongoing in our lab.
Acknowledgments
Financial support from the Natural Science Foundation of China (No. 31560152), the Open Project Program of Key Laboratory
of Functional Small Organic Molecule, Ministry of Education, Jiangxi Normal University (No. KLFS-KF-201721) and the Key
Discipline Project of Nanchang Normal University (No: NSXK20141003) are gratefully acknowledged.
A. Supplementary data
1
Experimental procedure, characterization data, H and 13C NMR spectra of compounds 3 and 4 can be found, in the online
version.
References and notes
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