Asymmetric Synthesis with α,β-Bis Ketones. Enantioselective Total Synthesis of Natural (+)-Indolizidine 195B (Bicyclic Gephyrotoxin 195B) and (-)-Pinidine and Their Enantiomers from a Common Chiral Synthon

Article abstract of DOI:10.1021/ja00186a038

The first enantioselective total synthesis of naturally occurring (+)-indolizidine 195B (bicyclic gephyrotoxin 195B) and (-)-pinidine and their enantiomers has been achieved starting from 4-O-benzyl-2,3-O-bis(methoxymethyl)-L-threitol as a single and comm