A New Series of Tricyclic (Aryloximino)propanolamines Displaying Very High Selective β2-Blocking Properties

Article abstract of DOI:10.1021/jm00122a008

A new class of indanones 4 easily obtained by aryne type condensations, followed by transposition of the benzocyclobutanols 3 thus formed, were transformed into the corresponding oximinopropanolamines 7.These compounds were studied for their potential β-blocking properties.It was found that 7 have generally low β₁-blocking properties.Their β₂-blocking action varies from low to very high.Interestingly one of them (7b) has the highest β₂ activity/β₁ activity (343) value known to date.