Synthesis, DNA-Binding Properties, and Antitumor Activity of Novel Distamycin Derivatives

DOI: 10.1021/jm00124a008

Source and publish data:

Journal of Medicinal Chemistry p. 774 - 778 (1989)

Update date:2022-08-05

Topics:

Authors:

Arcamone, Federico Maria

Animati, Fabio

Barbieri, Brunella

Configliacchi, Emanuela

D'Alessio, Roberto

et al. et al.

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Article abstract of DOI:10.1021/jm00124a008

A group of potential alkylating agents have been synthesized that are structurally related to the oligopeptide antiviral antibiotic distamycin.All derivatives from complexes with native calf-thymus DNA but compounds 2, 3, and 6 give rise to covalent adduc

Full text of DOI:10.1021/jm00124a008

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