Synthesis of oligodeoxyribonucleoside methylphosphonates containing 2- aminopurine

Article abstract of DOI:10.1080/07328319608002463

Oligodeoxyribonucleoside methylphosphonates containing multiple 2- aminopurine bases were synthesized by solid-phase phosphonamidite chemistry for investigating their triple helix formation with natural DNA or other duplex targets and for cellular uptake studies of the methylphosphonate oligomers. The base-labile phenoxyacetyl group was used as the N²-amino protecting group for 2-aminopurine, allowing the final deprotection of the oligomers to be performed under the standard ehtylenediamine condition.

Full text of DOI:10.1080/07328319608002463

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Nucleosides and Nucleotides
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Synthesis of Oligodeoxyribonucleoside
Methylphosphonates Containing 2-
Aminopurine
Yuanzhong Zhou a & Paul O P. Ts'o a
a Department of Biochemistry , School of Hygiene and Public Health
The Johns Hopkins University , Baltimore, Maryland, 21205, USA
Published online: 20 Aug 2006.
To cite this article: Yuanzhong Zhou & Paul O P. Ts'o (1996) Synthesis of Oligodeoxyribonucleoside
Methylphosphonates Containing 2-Aminopurine, Nucleosides and Nucleotides, 15:10, 1635-1648, DOI:
10.1080/07328319608002463
To link to this article: http://dx.doi.org/10.1080/07328319608002463
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