Matching active site and substrate structures for an RNA editing reaction

DOI: 10.1021/ja9034076

Source and publish data:

Journal of the American Chemical Society p. 11882 - 11891 (2009)

Update date:2022-07-29

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Authors:

Pokharel, Subhash

Jayalath, Prasanna

Maydanovych, Olena

Goodman, Rena A.

Wang, Selina C.

Tantillo, Dean J.

Beal, Peter A.

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Article abstract of DOI:10.1021/ja9034076

The RNA-editing adenosine deaminases (ADARs) catalyze deamination of adenosine to inosine in a double-stranded structure found in various RNA substrates, including mRNAs. Here we present recent efforts to define structure/activity relationships for the AD

Full text of DOI:10.1021/ja9034076

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