Phosphorus, Sulfur and Silicon and the Related Elements p. 753 - 765 (2009)
Update date:2022-07-30
Topics:
Behera, Rajani K.
Behera, Ajay K.
Pradhan, Rosy
Pati, Anita
Patra, Manabendra
Barbituric acid 2 upon Michael addition with dibenzal acetones 1a-c afforded the corresponding diazaspiro derivatives 3a-c. The base-catalyzed condensation of 3a-c with various aromatic aldehydes produces diarylidine derivatives 4a-l. The diarylidene compounds 4a-l on condensation with hydrazine, phenyl hydrazine, hydroxylamine, urea, guanidine carbonate, and hydrazine hydrate with acetic acid afforded their respective in situ oxidized products 5, 6, 7, 8, 9, and 10. The structures of the compounds are ascertained from their analytical and spectral data. Some of the compounds are screened for their biological activities against E. coli, B. cirroflagellosus, A. niger, and C. albicans.
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(2009)