An interrupted Ugi reaction enables the preparation of substituted indoxyls and aminoindoles

Article abstract of DOI:10.1016/j.tet.2008.08.055

In a variation of the classical Ugi reaction, an acid-promoted reaction between imines and isocyanides forms both 3-aminoindoles and substituted indoxyls. A recently reported triflyl phosphoramide is shown to be critical to obtain high yields under mild c