Journal of the American Chemical Society p. 2596 - 2599 (1989)
Update date:2022-08-04
Topics:
Wovkulich, P. M.
Tang, P. C.
Chadha, N. K.
Batcho, A. D.
Barrish, J. C.
Uskokovic, M. R.
The asymmetric total synthesis of mevinolin (1a) is described.The key diastereoselective processes used to parlay the lone stereogenic center of asymmetrically produced (S)-pulegone (2a) to mevinolin include orthoester-Claisen rearrangement of 2d to 3a, stereoselective iodolactonization of 3e to 4, Eschenmoser-Claisen rearrangement of 6 to 7a, stereoselective intramolecular ene reaction of 7b to 8, and a highly diastereoselective cyclocondesation of aldehyde 10 with Danishefsky's diene.The cyclocondensation reaction was found to be quite sensitive to the reactionconditions in which the use of TiCl4 produced a 90:10 mixture of 11/12 while MgBr2 gave a 22:78 mixture
View MoreHangzhou Eastbiopharm Co.,Ltd.
Contact:+86-571-88931780
Address:Hangzhou,China
Contact:(86) 731 88718666
Address:Room 1222, Unit 4, Building B, Shangcheng, No.47, Kaiyuan East Road.
HAINAN JINYING IMPORT AND EXPORT CO. LTD
Contact:+86-898-32875423
Address:A SECTION 19TH FL, TIMES SQUARE, NO.2 GUO MAO AVENUE HAIKOU, HAINAN, P. R. OF CHINA
Mollt Biochem Co., Ltd(expird)
Contact:+86-21-38682181
Address:shanghai ,china
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Contact:+86-21-5161 3915
Address:Shanghai YangPu
Doi:10.1007/s00706-008-0082-6
(2009)Doi:10.1016/j.poly.2019.03.042
(2019)Doi:10.1007/s11164-015-2113-3
(2016)Doi:10.1016/j.bmc.2015.11.014
(2015)Doi:10.1016/j.tetlet.2009.06.128
(2009)Doi:10.1021/ja00184a080
(1989)