Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors

DOI: 10.1016/j.bmc.2009.07.001

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Bioorganic and Medicinal Chemistry p. 5900 - 5905 (2009)

Update date:2022-08-05

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Authors:

Suzuki, Takayoshi

Imai, Keiko

Imai, Erika

Iida, Shinsuke

Ueda, Ryuzo

Tsumoto, Hiroki

Nakagawa, Hidehiko

Miyata, Naoki

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Article abstract of DOI:10.1016/j.bmc.2009.07.001

A series of 2-anilinobenzamide derivatives were designed, synthesized and evaluated for their SIRT1-inhibitory activity. Among these, compounds 3 and 5 inhibited SIRT1 activity in enzyme assays and suppressed the growth of Daudi and HCT116 cells.

Full text of DOI:10.1016/j.bmc.2009.07.001

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