Nucleosides, nucleotides and nucleic acids p. 261 - 274 (2009)
Update date:2022-08-05
Topics:
El-Sayed, Wael A.
Rashad, Aymn E.
Awad, Samir M.
Ali, Mamdouh M.
Some new thiopyrimidine acyclic nucleosides and thioglycoside derivatives 3a-c, 4a-c, 6a,b, and 7a,b were synthesized. The cytotoxicity and antitumor evaluation of all prepared compounds have been tested in vitro against Ehrlich's ascites carcinoma cell line and their activity against glutathione peroxidase and catalase were reported. The role of the prepared compounds as free radical regulators and the therapeutic antitumor effect of a balanced generation of free radicals are discussed. Compounds 2, 3b, 3c, 4a, and 4c inhibited significantly in a dose dependent manner the growth of Ehrlich ascites carcinoma cells while the other compounds did not show any antitumor activity even at higher concentrations.
View MoreRongCheng Tianyu Technology Co.,Ltd.
Contact:86-631-7519595
Address:220Ping Donghai Road RongChengCity,ShangDong Province China
Zhangjiagang Methese Composite Material Co.,
Contact:0512-85428658
Address:Shazhou Lake Technological Innovation Park,Zhangjiagang City,Jiangsu Province,China
Contact:+91 9963263336
Address:Plot#146A, IDA Mallapur, Hyderabad - 500072
Chemsigma International Co.,Ltd.
website:http://www.chemsigma.com
Contact:86-025-58748998
Address:Rm.705, 15th Building,Rd.Xinke II
Xinchang Yueding Chemical Co., Ltd.
Contact:86-571-56926323
Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG
Doi:10.1039/P19810000457
(1981)Doi:10.1021/jo00325a026
(1981)Doi:10.1016/j.ejmech.2019.111595
(2019)Doi:10.1002/hlca.19800630711
(1980)Doi:10.1016/S0040-4039(00)92870-3
(1980)Doi:10.1016/0040-4039(81)80164-5
(1981)