Bioorganic and Medicinal Chemistry Letters p. 5250 - 5255 (2009)
Update date:2022-08-04
Topics:
Tran, Thien-Duc
Adam, Fiona M.
Calo, Frederick
Fenwick, David R.
Fok-Seang, Juin
Gardner, Iain
Hay, Duncan A.
Perros, Manos
Rawal, Jaiessh
Middleton, Donald S.
Parkinson, Tanya
Pickford, Christopher
Platts, Michelle
Randall, Amy
Stephenson, Peter T.
Vuong, Hannah
Williams, David H.
The synthesis and structure-activity relationship of a series of novel gp120-CD4 inhibitors are described. Pharmacokinetic studies and antiviral spectrum assessment of lead compounds led to the identification of compound 36, a potent gp120-CD4 inhibitor w
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