Helvetica Chimica Acta p. 988 - 991 (1988)
Update date:2022-08-05
Topics:
Eichhorn, Thomas A.
Piesch,Steffen
Ried, Walter
The synthesis of new aryl (3,6-dichloro-4-pyridazinyl)ketones 3a-e via Friedel-Crafts acylation of the aromatic compounds 2a-e with 3,6-dichloro-4-pyridazinecarbonyl chloride (1) is described.The ketones 3a-e are cyclized with N,N-dinucleophilic reagents to the 3-aryl-5-chloro-1H-pyrazolo<3,4-c>pyridazines 4a-d, and 3a-c are converted into the 3-aryl-5-chloro-1H-pyrazolo<3,4-c>pyridazin-1-ethanols 5a-c and to the hitherto unknown ring system of the 5-aryl-3-chloro-7,8-dihydro-9H-pyridazino<3,4-e><1,4>diazepines (6a-c).
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Doi:10.1021/om00106a011
(1989)Doi:10.1021/ja00188a048
(1989)Doi:10.1002/chem.200802389
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(2020)Doi:10.1016/j.bmcl.2015.06.082
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(1988)
